BVF Partners Portfolio
13F Holdings & Position Changes — Last filed Feb 17, 2026
13F Holdings & Position Changes — Last filed Feb 17, 2026
BVF Partners is a $6B biotech-focused hedge fund managed by Mark Lampert. As of their latest 13F filing (Q4 2025), the fund holds 39 positions worth $2.9B. This quarter they initiated 2 new positions and exited 39. Their largest holding is KYMR ($428.2M).
BVF initiated 2 new positions and increased 8 this quarter. Portfolio grew +27.4% to $2.9B. 178 upcoming catalysts across holdings. 1 insider buy detected in portfolio companies.
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BVF Partners held 39 biotech stocks in their 13F portfolio this quarter. Their top positions include KYMR, RVMD, MLTX, GPCR, OLMA. The full holdings table is available on BiotechEdge with position sizes, quarter-over-quarter changes, and AI analysis.
BVF Partners's tracked biotech portfolio is worth $2.9B across 39 positions, with total assets under management of approximately $6B. Portfolio values are based on 13F filings with the SEC.
BVF Partners initiated 2 new positions this quarter, including IRON, IVVD. They also increased 8 existing positions.
BVF Partners fully exited 39 positions this quarter, including ROIV, UNCY, ANTX, CRVS, RLAY and 34 more. They also trimmed 7 existing positions.
Concentrated, value-oriented biotech fund that typically holds 15-25 positions. Lampert focuses on companies with underappreciated assets relative to their pipeline value, often building large positions and engaging constructively with management teams.
| 4 | GPCR | Increased | 3,479,022 | $242.0M |
| 5 | OLMA | 5,295,893 | $132.4M |
| 6 | MIRM | 1,495,290 | $118.1M |
| 7 | GHRS | 8,827,712 | $112.1M |
| 8 | XNCR | Increased | 7,133,720 | $109.2M |
| 9 | ZYME | 3,938,641 | $103.7M |
| 10 | KURA | 8,617,162 | $89.5M |
| 11 | STOK | Increased | 2,265,674 | $71.9M |
| 12 | XOMAP | 2,590,303 | $68.9M |
| 13 | AAVXF | Decreased | 508,031 | $68.5M |
| 14 | NKTR | Increased | 1,559,595 | $65.9M |
| 15 | ACIU | 19,822,436 | $62.2M |
| 16 | GLUE | Decreased | 3,835,886 | $60.1M |
| 17 | CGEM | 5,750,683 | $59.5M |
| 18 | TYRA | Decreased | 2,127,665 | $55.9M |
| 19 | IRON | New | 650,000 | $51.6M |
| 20 | IMCR | Decreased | 1,488,975 | $50.3M |
| 21 | IVVD | New | 19,525,000 | $48.2M |
| 22 | SEPN | Decreased | 1,720,782 | $48.0M |
| 23 | ANNX | Increased | 9,128,080 | $45.8M |
| 24 | CMPS | Increased | 7,764,842 | $41.7M |
| 25 | FDMT | 4,629,289 | $34.7M |
| 26 | CBIO | Increased | 2,748,763 | $32.6M |
| 27 | FHTX | 5,302,000 | $28.6M |
| 28 | AVTX | Increased | 1,355,257 | $24.6M |
| 29 | PEPG | 1,915,000 | $12.5M |
| 30 | ELDN | 6,293,282 | $9.5M |
| 31 | XFOR | 2,233,742 | $8.9M |
| 32 | AXSM | Decreased | 45,757 | $8.4M |
| 33 | MOLN | 1,353,968 | $5.8M |
| 34 | IMA | 802,102 | $5.5M |
| 35 | TCRX | 5,226,074 | $5.2M |
| 36 | TENX | 339,549 | $4.1M |
| 37 | IMUX | 7,652,972 | $4.1M |
| 38 | IVEVF | 686,040 | $3.2M |
| 39 | ENGNW | 945,402 | $2.4M |
| Q2 2025 |
| $2.7B |
| +14.6% |
| Q1 2025 | $2.4B | -16.8% |
| Q4 2024 | $2.8B | -12.6% |
| Q3 2024 | $3.2B | -1.6% |
| Q2 2024 | $3.3B | -1.0% |
| Q1 2024 | $3.3B | -9.0% |
| Q4 2023 | $3.7B | +9.7% |
| Q3 2023 | $3.3B | +4.2% |
| Q2 2023 | $3.2B | +39.5% |
| Q1 2023 | $2.3B | — |