Baker Bros. Advisors DSGN Position
Active9-Fund ConvergenceBaker Bros. Advisors increased their position in Design Therapeutics, Inc. (DSGN) in Q4 2025, holding $20.9M worth of shares across 2,233,099 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
DSGN is a convergence signal: 9 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 3 readout for Abiraterone - Usual in 34 days (May 18, 2026), making the timing of Baker Bros.'s position particularly relevant.
About Design Therapeutics, Inc.
Design Therapeutics, Inc. a preclinical-stage biopharmaceutical company, engages in the development of therapies for the treatment of genetic diseases caused by nucleotide repeat expansions. The company's portfolio of products comprises Friedreich Ataxia, a monogenic, autosomal recessive, progressive multi-system disease that affects organ systems dependent on mitochondrial function, eventually leading to neurological, cardiac, and metabolic dysfunction; and Myotonic Dystrophy Type-1 (DM1), a dominantly-inherited, monogenic progressive neuromuscular disease affecting skeletal muscle, heart, brain, and other organs. It is also developing GeneTAC product candidate portfolio for the treatment of other nucleotide repeat expansion-driven monogenic diseases, such as Fragile X syndrome, spinocerebellar ataxias, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington disease, and spinobulbar muscular atrophy. Design Therapeutics, Inc. was incorporated in 2017 and is headquartered in Carlsbad, California.
Full company profile →Short Interest
4.6%
9.6 days to cover
Baker Bros. Advisors DSGN Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Increased | 2,233,099 | +520,217 | $20.9M |
| Q3 2025 | Held | 1,712,882 | — | $12.9M |
| Q2 2025 | Decreased | 1,712,882 | -30,843 | $5.8M |
| Q1 2025 | Held | 1,743,725 | — | $6.7M |
| Q4 2024 | Held | 1,743,725 | — | $10.8M |
| Q3 2024 | Increased | 1,743,725 | +48,431 | $9.4M |
| Q2 2024 | Increased | 1,695,294 | +33,174 | $5.7M |
| Q1 2024 | Increased | 1,662,120 | +162,120 | $6.7M |
| Q4 2023 | Held | 1,500,000 | — | $4.0M |
| Q3 2023 | Increased | 1,500,000 | +1,000,000 | $3.5M |
| Q2 2023 | Decreased | 500,000 | -126,884 | $3.1M |
| Q1 2023 | New | 626,884 | +626,884 | $3.6M |
Frequently Asked Questions
Does Baker Bros. Advisors own DSGN?
Yes. As of Q4 2025, Baker Bros. Advisors holds 2,233,099 shares of Design Therapeutics, Inc. (DSGN) valued at $20.9M. This data comes from their SEC 13F filing.
How many hedge funds own DSGN?
9 specialist biotech hedge funds currently hold DSGN, including Cormorant Asset Management, Avoro Capital Advisors, RA Capital Management and 5 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did Baker Bros. Advisors first buy DSGN?
Baker Bros. Advisors's position in DSGN was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is Baker Bros. Advisors's DSGN position increasing or decreasing?
Baker Bros. Advisors increased their DSGN position in the most recent quarter, adding 520,217 shares.
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