Baker Bros. Advisors XENE Position
Active14-Fund ConvergenceBaker Bros. Advisors held their position in Xenon Pharmaceuticals Inc. (XENE) in Q4 2025, holding $16.6M worth of shares across 370,208 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
XENE is a convergence signal: 14 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 3 readout for Azetukalner in 139 days (Aug 31, 2026), making the timing of Baker Bros.'s position particularly relevant.
About Xenon Pharmaceuticals Inc.
Xenon Pharmaceuticals Inc., a clinical-stage biopharmaceutical company, engages in developing therapeutics to treat patients with neurological disorders in Canada. Its clinical development pipeline includes XEN496, A Kv7 potassium channel opener that is Phase III clinical trials for the treatment of KCNQ2 developmental and epilepsy encephalopathy; and XEN1101, A Kv7 potassium channel opener, which is in Phase II clinical trial for the treatment of epilepsy and other neurological disorders. The company's product candidates also comprise NBI-921352, a selective Nav1.6 sodium channel inhibitor that is in Phase II clinical trials for the treatment of SCN8A developmental and epileptic encephalopathy, and other potential indications, including adult focal epilepsy; and XEN007, A central nervous system-acting calcium channel modulator, which is in Phase II clinical trials. It has a license and collaboration agreement with the Neurocrine Biosciences, Inc. to develop treatments for epilepsy; and with Flexion Therapeutics, Inc. to develop PCRX301 (XEN402, a Nav1.7 inhibitor) for the treatment of post-operative pain. Xenon Pharmaceuticals Inc. was incorporated in 1996 and is headquartered in Burnaby, Canada.
Full company profile →Short Interest
6.2%
2.6 days to cover
Baker Bros. Advisors XENE Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Held | 370,208 | — | $16.6M |
| Q3 2025 | Held | 370,208 | — | $14.9M |
| Q2 2025 | Increased | 370,208 | +22,800 | $11.6M |
| Q1 2025 | Decreased | 347,408 | -646,271 | $11.7M |
| Q4 2024 | Held | 993,679 | — | $39.0M |
| Q3 2024 | Held | 993,679 | — | $39.1M |
| Q2 2024 | Held | 993,679 | — | $38.7M |
| Q1 2024 | Held | 993,679 | — | $42.8M |
| Q4 2023 | Increased | 993,679 | +242,040 | $45.8M |
| Q3 2023 | Held | 751,639 | — | $25.7M |
| Q2 2023 | Held | 751,639 | — | $28.9M |
| Q1 2023 | New | 751,639 | +751,639 | $26.9M |
Frequently Asked Questions
Does Baker Bros. Advisors own XENE?
Yes. As of Q4 2025, Baker Bros. Advisors holds 370,208 shares of Xenon Pharmaceuticals Inc. (XENE) valued at $16.6M. This data comes from their SEC 13F filing.
How many hedge funds own XENE?
14 specialist biotech hedge funds currently hold XENE, including Avoro Capital Advisors, Driehaus Capital, Commodore Capital and 10 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did Baker Bros. Advisors first buy XENE?
Baker Bros. Advisors's position in XENE was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is Baker Bros. Advisors's XENE position increasing or decreasing?
Baker Bros. Advisors held their XENE position unchanged in the most recent quarter.
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