Deerfield Management GPCR Position
Active16-Fund ConvergenceDeerfield Management increased their position in Structure Therapeutics Inc. (GPCR) in Q4 2025, holding $53.4M worth of shares across 767,993 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
GPCR is a convergence signal: 16 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 2 readout for Aleniglipron or Placebo in 106 days (Jul 31, 2026), making the timing of Deerfield's position particularly relevant.
About Structure Therapeutics Inc.
Structure Therapeutics Inc., a clinical stage global biopharmaceutical company, develops and delivers novel oral therapeutics to treat a range of chronic diseases with unmet medical needs. Its lead product candidate is GSBR-1290, an oral and biased small molecule agonist of glucagon-like-peptide-1 receptor, a validated G-protein-coupled receptors (GPCRs) drug target for type-2 diabetes mellitus and obesity. The company is also developing oral small molecule therapeutics targeting other GPCRs for the treatment of pulmonary and cardiovascular diseases, including ANPA-0073, a biased agonist, targeting apelin receptor, a GPCR that has been implicated in idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension; and LTSE-2578, an investigational oral small molecule lysophosphatidic acid 1 receptor antagonist for the treatment of IPF. The company was formerly known as ShouTi Inc. Structure Therapeutics Inc. was founded in 2016 and is headquartered in South San Francisco, California.
Full company profile →Short Interest
9.9%
6.5 days to cover
Deerfield Management GPCR Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Increased | 767,993 | +394,586 | $53.4M |
| Q3 2025 | Held | 373,407 | — | $10.5M |
| Q2 2025 | Held | 373,407 | — | $7.7M |
| Q1 2025 | Held | 373,407 | — | $6.5M |
| Q4 2024 | Decreased | 373,407 | -471,000 | $10.1M |
| Q3 2024 | Held | 844,407 | — | $37.1M |
| Q2 2024 | Decreased | 844,407 | -189,273 | $33.2M |
| Q1 2024 | Increased | 1,033,680 | +210,867 | $44.3M |
| Q4 2023 | Increased | 822,813 | +195,000 | $33.5M |
| Q3 2023 | Held | 627,813 | — | $31.7M |
| Q2 2023 | Increased | 627,813 | +252,813 | $26.1M |
| Q1 2023 | New | 375,000 | +375,000 | $8.9M |
Frequently Asked Questions
Does Deerfield Management own GPCR?
Yes. As of Q4 2025, Deerfield Management holds 767,993 shares of Structure Therapeutics Inc. (GPCR) valued at $53.4M. This data comes from their SEC 13F filing.
How many hedge funds own GPCR?
16 specialist biotech hedge funds currently hold GPCR, including Avoro Capital Advisors, Deep Track Capital, BVF Partners and 12 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did Deerfield Management first buy GPCR?
Deerfield Management's position in GPCR was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is Deerfield Management's GPCR position increasing or decreasing?
Deerfield Management increased their GPCR position in the most recent quarter, adding 394,586 shares.
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