EcoR1 Capital Portfolio
13F Holdings & Position Changes — Last filed Aug 14, 2026
13F Holdings & Position Changes — Last filed Aug 14, 2026
Growth-stage crossover fund investing in life sciences companies from late-stage private rounds through public equity. Named after the EcoR1 restriction enzyme, reflecting the firm's scientific roots. Focuses on platform technologies and novel therapeutic modalities.
EcoR1 Capital is a $5B biotech-focused hedge fund managed by Oleg Nodelman. As of their latest 13F filing (Q2 2026), the fund holds 31 positions worth $2.0B. This quarter they initiated 9 new positions and exited 88. Their largest holding is ZYME ($600.4M).
EcoR1 initiated 9 new positions and increased 4 this quarter. Portfolio shrank -13.8% to $2.0B. 294 upcoming catalysts across holdings. 92 insider buys detected in portfolio companies.
Portfolio Value (13F)
$2.0B
Holdings
31
Top 10 Concentration
88.0%
QoQ Change
-13.8%
Turnover
7.3%
Portfolio Value Trend
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| # | Ticker | Company | Change | Value | % of Portfolio | SI % Float ? | Trend |
|---|---|---|---|---|---|---|---|
| 1 | ZYME | Zymeworks Inc. | $600.4M | 29.77% | 11.2% | ||
| 2 | ANAB | AnaptysBio Inc. | $531.9M | 26.37% | 38.5% | ||
| 3 | AKTS | Aktis Oncology, Inc. | $155.5M | 7.71% | 29.2% | ||
| 4 | CGON | CG Oncology, Inc. | Increased↑3Q | $106.2M | 5.26% | 12.0% | |
| 5 | ETON | Eton Pharmaceuticals, Inc. | $78.6M | 3.90% | 8.9% | ||
| 6 | CRSP | CRISPR Therapeutics AG | $75.8M | 3.76% | 22.1% | ||
| 7 | ORIC | ORIC Pharmaceuticals Inc. | $72.9M | 3.61% | 15.9% | ||
| 8 | FHN-PH | First Horizon Corp. | New | $63.9M | 3.17% | — | — |
| 9 | GLPGF | Galapagos NV | $50.0M | 2.48% | — | ||
| 10 | NGNE | Neurogene Inc. | $40.0M | 1.98% | 29.5% |
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EcoR1 Capital held 31 biotech stocks in their 13F portfolio this quarter. Their top positions include ZYME, ANAB, AKTS, CGON, ETON. The full holdings table is available on BiotechEdge with position sizes, quarter-over-quarter changes, and AI analysis.
EcoR1 Capital's tracked biotech portfolio is worth $2.0B across 31 positions, with total assets under management of approximately $5B. Portfolio values are based on 13F filings with the SEC.
EcoR1 Capital initiated 9 new positions this quarter, including FHN-PH, FULC, LEGN, AURA, ODTX and 4 more. They also increased 4 existing positions.
EcoR1 Capital fully exited 88 positions this quarter, including PSTX, VRNA, JANX, CGEM, DAWN and 83 more. They also trimmed 4 existing positions.
Growth-stage crossover fund investing in life sciences companies from late-stage private rounds through public equity. Named after the EcoR1 restriction enzyme, reflecting the firm's scientific roots. Focuses on platform technologies and novel therapeutic modalities.
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