In Q4 2025, EcoR1 Capital held 27 positions worth $2.2B. They initiated 8 new positions and exited 78. Their largest holding was ZYME ($604.8M). Portfolio value grew +5.9% versus the prior quarter.
Frequently asked questions
What stocks did EcoR1 Capital own in Q4 2025?
EcoR1 Capital held 27 biotech stocks in their 13F portfolio in Q4 2025. Their top positions include ZYME, ANAB, JAZZ, CRNX, CNTA. The full holdings table is available on BiotechEdge with position sizes, quarter-over-quarter changes, and AI analysis.
How much was EcoR1 Capital's portfolio worth in Q4 2025?
EcoR1 Capital's tracked biotech portfolio was worth $2.2B across 27 positions, with total assets under management of approximately $5B. Portfolio values are based on 13F filings with the SEC.
What did EcoR1 Capital buy in Q4 2025?
EcoR1 Capital initiated 8 new positions in Q4 2025, including CGON, ZBIO, GPCR, MNKD, EOLS and 3 more. They also increased 3 existing positions.
What did EcoR1 Capital sell in Q4 2025?
EcoR1 Capital fully exited 78 positions in Q4 2025, including VERV, CLDX, EWTX, PRLD, ARQT and 73 more. They also trimmed 2 existing positions.
Is EcoR1 Capital a biotech fund?
Growth-stage crossover fund investing in life sciences companies from late-stage private rounds through public equity. Named after the EcoR1 restriction enzyme, reflecting the firm's scientific roots. Focuses on platform technologies and novel therapeutic modalities.
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