OrbiMed Advisors ARGX Position
Active12-Fund ConvergenceOrbiMed Advisors trimmed their position in argenx SE (ARGX) in Q4 2025, holding $122.8M worth of shares across 146,000 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
ARGX is a convergence signal: 12 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 2 readout for Efgartigimod in 106 days (Jul 31, 2026), making the timing of OrbiMed's position particularly relevant.
About argenx SE
argenx SE, a biotechnology company, engages in the developing of various therapies for the treatment of autoimmune diseases in the United States, Japan, Europe, Middle East, Africa, and China. Its lead product candidate is efgartigimod for the treatment of patients with myasthenia gravis, immune thrombocytopenia, pemphigus vulgaris, generalized myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, thyroid eye disease, bullous pemphigoid, myositis, primary sjögren's syndrome, post-covid postural orthostatic tachycardia syndrome, membranous nephropathy, lupus nephropathy, anca-associated vasculitis, and antibody mediated rejection; ENHANZE SC; Empasiprubart for multifocal motor neuropath, delayed graft function, and dermatomyositis; and ARGX-119 for congenital myasthenic syndrome and amyotrophic lateral sclerosis. The company is developing ARGX-213 targets FcRn; ARGX-121 and ARGX-220 targets immune system; ARGX-109 targets IL-6; ARGX-118 for inflammation; and ARGX-109, as well as cusatuzumab, ARGX-112, ARGX-114, and ARGX-115. It owns VYVGART; VYVGART HYTRULO; VYVDURA; ARGENX; ABDEG; NHANCE; SIMPLE ANTIBODY; and ARGENXMEDHUB. The company has strategic partnership with AbbVie S.À.R.L., Zai Lab Limited, and LEO Pharma A/S; and collaboration and license agreement with Genor Biopharma Co. Ltd, Université Catholique de Louvain, Sopartec S.A., NYU Langone Health, Leiden University Medical Center, AgomAb Therapeutics NV, Broteio Pharma B.V., VIB vzw, University of Texas, BioWa, Inc., and Shire International GmbH. It has collaboration agreement with Genmab A/S to discover, develop, and commercialize novel therapeutic antibodies with applications in immunology and oncology, as well as a strategic collaboration with IQVIA Holdings Inc. to provide safety systems and services. argenx SE was incorporated in 2008 and is based in Amsterdam, the Netherlands.
Full company profile →Short Interest
3.4%
5.1 days to cover
OrbiMed Advisors ARGX Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Decreased | 146,000 | -26,300 | $122.8M |
| Q3 2025 | Decreased | 172,300 | -35,700 | $127.1M |
| Q2 2025 | Increased | 208,000 | +1,300 | $114.7M |
| Q1 2025 | Increased | 206,700 | +17,000 | $122.3M |
| Q4 2024 | Decreased | 189,700 | -14,800 | $116.7M |
| Q3 2024 | Decreased | 204,500 | -4,600 | $110.9M |
| Q2 2024 | Increased | 209,100 | +57,500 | $89.9M |
| Q1 2024 | Increased | 151,600 | +67,000 | $59.7M |
| Q4 2023 | Increased | 84,600 | +52,000 | $32.2M |
| Q3 2023 | Held | 32,600 | — | $16.0M |
| Q2 2023 | Decreased | 32,600 | -11,900 | $12.7M |
| Q1 2023 | New | 44,500 | +44,500 | $16.6M |
Frequently Asked Questions
Does OrbiMed Advisors own ARGX?
Yes. As of Q4 2025, OrbiMed Advisors holds 146,000 shares of argenx SE (ARGX) valued at $122.8M. This data comes from their SEC 13F filing.
How many hedge funds own ARGX?
12 specialist biotech hedge funds currently hold ARGX, including Avoro Capital Advisors, RTW Investments, Deep Track Capital and 8 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did OrbiMed Advisors first buy ARGX?
OrbiMed Advisors's position in ARGX was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is OrbiMed Advisors's ARGX position increasing or decreasing?
OrbiMed Advisors trimmed their ARGX position in the most recent quarter, reducing by 26,300 shares.
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