OrbiMed Advisors DYN Position
Active13-Fund ConvergenceOrbiMed Advisors trimmed their position in Dyne Therapeutics Inc. (DYN) in Q4 2025, holding $43.1M worth of shares across 2,202,184 shares.
The position was first reported in Q1 2024 and has been tracked across 8 quarterly 13F filings.
DYN is a convergence signal: 13 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 3 readout for DYNE-101 in 837 days (Jul 31, 2028), making the timing of OrbiMed's position particularly relevant.
Short interest stands at 12.7% of float with 8.1 days to cover, indicating significant bearish positioning against OrbiMed's long thesis.
1 insider purchase totaling $34K has been filed in the last 90 days, providing an additional conviction signal.
About Dyne Therapeutics Inc.
Dyne Therapeutics, Inc., a muscle disease company, operates as a biotechnology company that focuses on advancing therapeutics for genetically driven muscle diseases in the United States. It develops various programs for myotonic dystrophy type 1, duchenne muscular dystrophy, and facioscapulohumeral dystrophy, as well as rare skeletal muscle, and cardiac and metabolic muscle diseases using its FORCE platform that delivers disease-modifying therapeutics. The company was incorporated in 2017 and is headquartered in Waltham, Massachusetts..
Full company profile →Short Interest
12.7%
8.1 days to cover
Insider Buys (90d)
1
$34K total
OrbiMed Advisors DYN Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Decreased | 2,202,184 | -112,000 | $43.1M |
| Q3 2025 | Increased | 2,314,184 | +1,282,784 | $29.3M |
| Q2 2025 | Increased | 1,031,400 | +16,789 | $9.8M |
| Q1 2025 | Decreased | 1,014,611 | -212,469 | $10.6M |
| Q4 2024 | Increased | 1,227,080 | +518,680 | $28.9M |
| Q3 2024 | Held | 708,400 | — | $25.4M |
| Q2 2024 | Held | 708,400 | — | $25.0M |
| Q1 2024 | New | 708,400 | +708,400 | $20.1M |
Frequently Asked Questions
Does OrbiMed Advisors own DYN?
Yes. As of Q4 2025, OrbiMed Advisors holds 2,202,184 shares of Dyne Therapeutics Inc. (DYN) valued at $43.1M. This data comes from their SEC 13F filing.
How many hedge funds own DYN?
13 specialist biotech hedge funds currently hold DYN, including RTW Investments, RA Capital Management, Deep Track Capital and 9 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did OrbiMed Advisors first buy DYN?
OrbiMed Advisors's position in DYN was first reported in Q1 2024. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is OrbiMed Advisors's DYN position increasing or decreasing?
OrbiMed Advisors trimmed their DYN position in the most recent quarter, reducing by 112,000 shares.
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