OrbiMed Advisors LXEO Position
Active5-Fund ConvergenceOrbiMed Advisors initiated a new position in Lexeo Therapeutics, Inc. (LXEO) in Q4 2025, holding $21.1M worth of shares across 2,125,000 shares.
LXEO is a convergence signal: 5 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 2 readout in 259 days (Dec 31, 2026), making the timing of OrbiMed's position particularly relevant.
Short interest stands at 17.3% of float with 14.4 days to cover, indicating significant bearish positioning against OrbiMed's long thesis.
About Lexeo Therapeutics, Inc.
Lexeo Therapeutics, Inc. operates as a clinical-stage genetic medicine company that focuses on hereditary and acquired diseases. The company develops LX2006, which is an AAVrh10-based gene therapy candidate for the treatment of Friedreich's ataxia (FA) cardiomyopathy; LX2020, an AAVrh10-based gene therapy candidate for the treatment of arrhythmogenic cardiomyopathy; LX2021, a gene therapy candidate for the treatment of DSP cardiomyopathy associated with it; and LX2022, a gene therapy candidate for the treatment of HCM caused by TNNI3 mutations. It also develops LX1001, an AAVrh10-based gene therapy candidate for the treatment of APOE4 homozygous; LX1020, a gene therapy candidate for the treatment of APOE4 homozygous; LX1021 for the treatment of APOE4 homozygotes; and LX1004 for the treatment of CLN2 Batten disease. The company was incorporated in 2017 and is based in New York, New York.
Full company profile →Short Interest
17.3%
14.4 days to cover
Frequently Asked Questions
Does OrbiMed Advisors own LXEO?
Yes. As of Q4 2025, OrbiMed Advisors holds 2,125,000 shares of Lexeo Therapeutics, Inc. (LXEO) valued at $21.1M. This data comes from their SEC 13F filing.
How many hedge funds own LXEO?
5 specialist biotech hedge funds currently hold LXEO, including Eventide Asset Management, RA Capital Management, Avoro Capital Advisors and 1 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did OrbiMed Advisors first buy LXEO?
OrbiMed Advisors's position in LXEO was first reported in Q4 2025. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is OrbiMed Advisors's LXEO position increasing or decreasing?
OrbiMed Advisors initiated a new position in LXEO in the most recent quarter. This is their first reported holding.
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