OrbiMed Advisors PRLD Position
Active5-Fund ConvergenceOrbiMed Advisors held their position in Prelude Therapeutics Inc. (PRLD) in Q4 2025, holding $31.6M worth of shares across 10,909,256 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
PRLD is a convergence signal: 5 specialist biotech funds hold this stock, suggesting high institutional conviction.
Short interest stands at 19.0% of float with 6.5 days to cover, indicating significant bearish positioning against OrbiMed's long thesis.
About Prelude Therapeutics Inc.
Prelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT543 that is in Phase 1 clinical trials in select solid tumors and myeloid malignancies; and PRT811, which is in Phase 1 clinical trials in solid tumors, including glioblastoma multiforme. The company is also developing PRT1419, a potent and selective inhibitor of the anti-apoptotic protein; PRT2527, a potent inhibitor of CDK9 that exhibits high kinome selectivity; PRT-SCA2, which is in preclinical stage for multiple genomically selected cancers; PRT3645, a brain penetrant molecule that potently and selectively targets CDK4/6; and PRT-K4 that is in preclinical stage for solid tumors. The company was incorporated in 2016 and is headquartered in Wilmington, Delaware.
Full company profile →Short Interest
19.0%
6.5 days to cover
OrbiMed Advisors PRLD Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Held | 10,909,256 | — | $31.6M |
| Q3 2025 | Held | 10,909,256 | — | $15.7M |
| Q2 2025 | Held | 10,909,256 | — | $8.8M |
| Q1 2025 | Held | 10,909,256 | — | $8.4M |
| Q4 2024 | Held | 10,909,256 | — | $13.9M |
| Q3 2024 | Held | 10,909,256 | — | $22.6M |
| Q2 2024 | Held | 10,909,256 | — | $41.6M |
| Q1 2024 | Held | 10,909,256 | — | $51.7M |
| Q4 2023 | Held | 10,909,256 | — | $46.6M |
| Q3 2023 | Held | 10,909,256 | — | $33.7M |
| Q2 2023 | Increased | 10,909,256 | +869,565 | $49.1M |
| Q1 2023 | New | 10,039,691 | +10,039,691 | $57.2M |
Frequently Asked Questions
Does OrbiMed Advisors own PRLD?
Yes. As of Q4 2025, OrbiMed Advisors holds 10,909,256 shares of Prelude Therapeutics Inc. (PRLD) valued at $31.6M. This data comes from their SEC 13F filing.
How many hedge funds own PRLD?
5 specialist biotech hedge funds currently hold PRLD, including Baker Bros. Advisors, Deerfield Management, Boxer Capital and 1 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did OrbiMed Advisors first buy PRLD?
OrbiMed Advisors's position in PRLD was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is OrbiMed Advisors's PRLD position increasing or decreasing?
OrbiMed Advisors held their PRLD position unchanged in the most recent quarter.
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