Perceptive Advisors ALDX Position
ActivePerceptive Advisors trimmed their position in Aldeyra Therapeutics Inc. (ALDX) in Q4 2025, holding $21.7M worth of shares across 4,185,632 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
1 other tracked fund also holds ALDX.
There is an upcoming Phase 3 readout for ICM ADX-2191 injection in 259 days (Dec 31, 2026), making the timing of Perceptive's position particularly relevant.
Short interest stands at 11.0% of float with 5.3 days to cover, indicating significant bearish positioning against Perceptive's long thesis.
About Aldeyra Therapeutics Inc.
Aldeyra Therapeutics, Inc., a biotechnology company, develops and commercializes medicines for immune-mediated ocular and systemic diseases. The company's lead product candidate is reproxalap, a reactive aldehyde species (RASP)modulator, which is in Phase III clinical trial for the treatment of dry eye diseases and allergic conjunctivitis. It also develops ADX-629, a first-in-class orally administered RASP modulator that is Phase II clinical trial for psoriasis, asthma, and COVID-19; and ADX-2191, a dihydrofolate reductase inhibitor which is in phase 3 for the prevention of proliferative vitreoretinopathy, and phase II clinical trial for the treatment of retinitis pigmentosa, as well as for treating primary vitreoretinal lymphoma. The company has a license agreement with Madrigal Pharmaceuticals, Inc. for developing ADX-1612, which inhibits the protein chaperome for the treatment of inflammatory diseases. The company was formerly known as Aldexa Therapeutics, Inc. and changed its name to Aldeyra Therapeutics, Inc. in March 2014. Aldeyra Therapeutics, Inc. was incorporated in 2004 and is based in Lexington, Massachusetts.
Full company profile →Short Interest
11.0%
5.3 days to cover
Perceptive Advisors ALDX Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Decreased | 4,185,632 | -1,036,679 | $21.7M |
| Q3 2025 | Increased | 5,222,311 | +1,170,680 | $27.3M |
| Q2 2025 | Decreased | 4,051,631 | -5,224,220 | $15.5M |
| Q1 2025 | Held | 9,275,851 | — | $53.3M |
| Q4 2024 | Held | 9,275,851 | — | $46.3M |
| Q3 2024 | Held | 9,275,851 | — | $50.0M |
| Q2 2024 | Increased | 9,275,851 | +682,265 | $30.7M |
| Q1 2024 | Held | 8,593,586 | — | $28.1M |
| Q4 2023 | Decreased | 8,593,586 | -2,756,499 | $30.2M |
| Q3 2023 | Held | 11,350,085 | — | $75.8M |
| Q2 2023 | Held | 11,350,085 | — | $95.2M |
| Q1 2023 | New | 11,350,085 | +11,350,085 | $112.7M |
Frequently Asked Questions
Does Perceptive Advisors own ALDX?
Yes. As of Q4 2025, Perceptive Advisors holds 4,185,632 shares of Aldeyra Therapeutics Inc. (ALDX) valued at $21.7M. This data comes from their SEC 13F filing.
How many hedge funds own ALDX?
2 specialist biotech hedge funds currently hold ALDX, including Deerfield Management. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did Perceptive Advisors first buy ALDX?
Perceptive Advisors's position in ALDX was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is Perceptive Advisors's ALDX position increasing or decreasing?
Perceptive Advisors trimmed their ALDX position in the most recent quarter, reducing by 1,036,679 shares.
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