Redmile Group KRYS Position
Active9-Fund ConvergenceRedmile Group increased their position in Krystal Biotech Inc. (KRYS) in Q4 2025, holding $167.1M worth of shares across 677,705 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
KRYS is a convergence signal: 9 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 3 readout for KB803 in 259 days (Dec 31, 2026), making the timing of Redmile's position particularly relevant.
Short interest stands at 16.4% of float with 9.2 days to cover, indicating significant bearish positioning against Redmile's long thesis.
About Krystal Biotech Inc.
Krystal Biotech, Inc., a clinical stage biotechnology company, engages in the field of redosable gene therapy to treat serious rare diseases in the United States. Its lead product candidate is beremagene geperpavec (B-VEC), which is in Phase III clinical study to treat dystrophic epidermolysis bullosa. The company is also involved in developing KB105 that is in Phase I/II clinical study for treating patients with deficient autosomal recessive congenital ichthyosis; KB301, which is in Phase I/II clinical stage for treating wrinkles and other presentations of aged or damaged skin; KB407 that is in preclinical stage for cystic fibrosis; and KB104, which is in preclinical stage for netherton syndrome. Its discovery stage product candidates include KB5xx for treating chronic skin diseases, KB3xx to treat aesthetic skin conditions, and KB3xx product. Krystal Biotech, Inc. was founded in 2015 and is headquartered in Pittsburgh, Pennsylvania.
Full company profile →Short Interest
16.4%
9.2 days to cover
Redmile Group KRYS Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Increased | 677,705 | +16,317 | $167.1M |
| Q3 2025 | Decreased | 661,388 | -2,083 | $116.8M |
| Q2 2025 | Decreased | 663,471 | -74,204 | $91.2M |
| Q1 2025 | Decreased | 737,675 | -15,500 | $133.0M |
| Q4 2024 | Decreased | 753,175 | -57,070 | $118.0M |
| Q3 2024 | Decreased | 810,245 | -210,833 | $147.5M |
| Q2 2024 | Decreased | 1,021,078 | -487,172 | $187.5M |
| Q1 2024 | Decreased | 1,508,250 | -224,939 | $268.4M |
| Q4 2023 | Decreased | 1,733,189 | -270,178 | $215.0M |
| Q3 2023 | Decreased | 2,003,367 | -563,294 | $232.4M |
| Q2 2023 | Increased | 2,566,661 | +653,381 | $301.3M |
| Q1 2023 | New | 1,913,280 | +1,913,280 | $153.2M |
Frequently Asked Questions
Does Redmile Group own KRYS?
Yes. As of Q4 2025, Redmile Group holds 677,705 shares of Krystal Biotech Inc. (KRYS) valued at $167.1M. This data comes from their SEC 13F filing.
How many hedge funds own KRYS?
9 specialist biotech hedge funds currently hold KRYS, including Avoro Capital Advisors, Baker Bros. Advisors, Driehaus Capital and 5 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did Redmile Group first buy KRYS?
Redmile Group's position in KRYS was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is Redmile Group's KRYS position increasing or decreasing?
Redmile Group increased their KRYS position in the most recent quarter, adding 16,317 shares.
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