BVF Partners SYRE Position
Exited15-Fund ConvergenceBVF Partners exited their position in Spyre Therapeutics, Inc. (SYRE) in Q1 2024, after holding the stock for 2 quarters.
The position was first reported in Q4 2023 and has been tracked across 2 quarterly 13F filings.
SYRE is a convergence signal: 15 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 2 readout for SPY001 in 75 days (Jun 30, 2026), making the timing of BVF's position particularly relevant.
Short interest stands at 15.3% of float with 12.1 days to cover, indicating significant bearish positioning against the stock.
About Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.
Full company profile →Short Interest
15.3%
12.1 days to cover
BVF Partners SYRE Position History
Frequently Asked Questions
Does BVF Partners own SYRE?
No. BVF Partners exited their position in Spyre Therapeutics, Inc. (SYRE) in Q1 2024. They previously held the stock for 2 quarters.
How many hedge funds own SYRE?
15 specialist biotech hedge funds currently hold SYRE, including RTW Investments, Perceptive Advisors, Driehaus Capital and 12 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did BVF Partners first buy SYRE?
BVF Partners's position in SYRE was first reported in Q4 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is BVF Partners's SYRE position increasing or decreasing?
BVF Partners completely exited their SYRE position in the most recent quarter.
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