RTW Investments APGE Position
Active12-Fund ConvergenceRTW Investments held their position in Apogee Therapeutics Inc. (APGE) in Q4 2025, holding $204.7M worth of shares across 2,712,097 shares.
The position was first reported in Q3 2023 and has been tracked across 10 quarterly 13F filings.
APGE is a convergence signal: 12 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 2 readout for APG777 in 228 days (Nov 30, 2026), making the timing of RTW Investments's position particularly relevant.
Short interest stands at 23.2% of float with 10.9 days to cover, indicating significant bearish positioning against RTW Investments's long thesis.
About Apogee Therapeutics Inc.
Apogee Therapeutics, Inc., through its subsidiary, operates as a biotechnology company that develops biologics for the treatment of atopic dermatitis (AD), chronic obstructive pulmonary disease (COPD), and related inflammatory and immunology indications. The company primarily develops APG777, a subcutaneous (SQ) extended half-life monoclonal antibody (mAb) for AD; and APG808, an SQ extended half-life mAb for COPD. Its earlier-stage programs include APG990, an SQ extended half-life mAb for the treatment of AD; and APG222, an extended half-life SQ antibodies for AD. The company was founded in 2022 and is based in Waltham, Massachusetts.
Full company profile →Short Interest
23.2%
10.9 days to cover
RTW Investments APGE Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Held | 2,712,097 | — | $204.7M |
| Q3 2025 | Held | 2,712,097 | — | $107.8M |
| Q2 2025 | Held | 2,712,097 | — | $117.8M |
| Q1 2025 | Held | 2,712,097 | — | $101.3M |
| Q4 2024 | Increased | 2,712,097 | +1 | $122.9M |
| Q3 2024 | Held | 2,712,096 | — | $159.3M |
| Q2 2024 | Increased | 2,712,096 | +244,505 | $106.7M |
| Q1 2024 | Increased | 2,467,591 | +325,000 | $164.0M |
| Q4 2023 | Held | 2,142,591 | — | $59.9M |
| Q3 2023 | New | 2,142,591 | +2,142,591 | $45.6M |
Frequently Asked Questions
Does RTW Investments own APGE?
Yes. As of Q4 2025, RTW Investments holds 2,712,097 shares of Apogee Therapeutics Inc. (APGE) valued at $204.7M. This data comes from their SEC 13F filing.
How many hedge funds own APGE?
12 specialist biotech hedge funds currently hold APGE, including Perceptive Advisors, Driehaus Capital, Deep Track Capital and 8 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did RTW Investments first buy APGE?
RTW Investments's position in APGE was first reported in Q3 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is RTW Investments's APGE position increasing or decreasing?
RTW Investments held their APGE position unchanged in the most recent quarter.
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