RTW Investments AXSM Position
Active11-Fund ConvergenceRTW Investments trimmed their position in Axsome Therapeutics Inc. (AXSM) in Q4 2025, holding $162.2M worth of shares across 888,001 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
AXSM is a convergence signal: 11 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 2 readout for Solriamfetol in 229 days (Dec 1, 2026), making the timing of RTW Investments's position particularly relevant.
About Axsome Therapeutics Inc.
Axsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's product pipeline includes AXS-05, a therapeutic for the treatment of major depressive disorder and resistant depression disorders; and that is in the Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation. It is also developing AXS-07, a novel, oral, rapidly absorbed, multi-mechanistic, and investigational medicine that has completed two Phase III trials for the acute treatment of migraine; AXS-12, a selective and potent norepinephrine reuptake inhibitor, which is in Phase III trial to treat narcolepsy; and AXS-14, a novel, oral, and investigational medicine that is in Phase III trial for the treatment of fibromyalgia. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.
Full company profile →Short Interest
6.4%
4.5 days to cover
RTW Investments AXSM Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Decreased | 888,001 | -230,882 | $162.2M |
| Q3 2025 | Decreased | 1,118,883 | -398,020 | $135.9M |
| Q2 2025 | Decreased | 1,516,903 | -1,405,826 | $158.3M |
| Q1 2025 | Decreased | 2,922,729 | -1,128,636 | $340.9M |
| Q4 2024 | Decreased | 4,051,365 | -138,192 | $342.8M |
| Q3 2024 | Decreased | 4,189,557 | -444,774 | $376.5M |
| Q2 2024 | Increased | 4,634,331 | +141,652 | $373.1M |
| Q1 2024 | Increased | 4,492,679 | +3,083 | $358.5M |
| Q4 2023 | Held | 4,489,596 | — | $357.3M |
| Q3 2023 | Increased | 4,489,596 | +205,319 | $313.8M |
| Q2 2023 | Increased | 4,284,277 | +503,422 | $307.9M |
| Q1 2023 | New | 3,780,855 | +3,780,855 | $233.2M |
Frequently Asked Questions
Does RTW Investments own AXSM?
Yes. As of Q4 2025, RTW Investments holds 888,001 shares of Axsome Therapeutics Inc. (AXSM) valued at $162.2M. This data comes from their SEC 13F filing.
How many hedge funds own AXSM?
11 specialist biotech hedge funds currently hold AXSM, including Deep Track Capital, BVF Partners, Eventide Asset Management and 7 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did RTW Investments first buy AXSM?
RTW Investments's position in AXSM was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is RTW Investments's AXSM position increasing or decreasing?
RTW Investments trimmed their AXSM position in the most recent quarter, reducing by 230,882 shares.
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