RTW Investments MDGL Position
Active11-Fund ConvergenceRTW Investments held their position in Madrigal Pharmaceuticals Inc. (MDGL) in Q4 2025, holding $1.2B worth of shares across 1,993,687 shares.
The position was first reported in Q2 2023 and has been tracked across 11 quarterly 13F filings.
MDGL is a convergence signal: 11 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 3 readout for Resmetirom in 259 days (Dec 31, 2026), making the timing of RTW Investments's position particularly relevant.
Short interest stands at 19.8% of float with 10.6 days to cover, indicating significant bearish positioning against RTW Investments's long thesis.
About Madrigal Pharmaceuticals Inc.
Madrigal Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of therapeutic candidates for the treatment of cardiovascular, metabolic, and liver diseases. Its lead product candidate is resmetirom, a liver-directed selective thyroid hormone receptor-ß agonist, which is in Phase III clinical trials for the treatment of non-alcoholic steatohepatitis. The company also develops MGL-3745, a backup compound to resmetirom. It has research, development, and commercialization agreement with Hoffmann-La Roche. Madrigal Pharmaceuticals, Inc. is headquartered in West Conshohocken, Pennsylvania.
Full company profile →Short Interest
19.8%
10.6 days to cover
RTW Investments MDGL Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Held | 1,993,687 | — | $1.2B |
| Q3 2025 | Held | 1,993,687 | — | $914.4M |
| Q2 2025 | Held | 1,993,687 | — | $603.4M |
| Q1 2025 | Held | 1,993,687 | — | $660.4M |
| Q4 2024 | Held | 1,993,687 | — | $615.2M |
| Q3 2024 | Increased | 1,993,687 | +77,825 | $423.1M |
| Q2 2024 | Increased | 1,915,862 | +1,518,815 | $536.7M |
| Q1 2024 | Decreased | 397,047 | -418,144 | $106.0M |
| Q4 2023 | Increased | 815,191 | +505,706 | $188.6M |
| Q3 2023 | Increased | 309,485 | +87,923 | $45.2M |
| Q2 2023 | New | 221,562 | +221,562 | $51.2M |
Frequently Asked Questions
Does RTW Investments own MDGL?
Yes. As of Q4 2025, RTW Investments holds 1,993,687 shares of Madrigal Pharmaceuticals Inc. (MDGL) valued at $1.2B. This data comes from their SEC 13F filing.
How many hedge funds own MDGL?
11 specialist biotech hedge funds currently hold MDGL, including Baker Bros. Advisors, Avoro Capital Advisors, Perceptive Advisors and 7 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did RTW Investments first buy MDGL?
RTW Investments's position in MDGL was first reported in Q2 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is RTW Investments's MDGL position increasing or decreasing?
RTW Investments held their MDGL position unchanged in the most recent quarter.
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