RTW Investments XNCR Position
Active10-Fund ConvergenceRTW Investments increased their position in Xencor Inc. (XNCR) in Q4 2025, holding $103.8M worth of shares across 6,777,461 shares.
The position was first reported in Q3 2024 and has been tracked across 6 quarterly 13F filings.
XNCR is a convergence signal: 10 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 2 readout for XmAb20717 in 230 days (Dec 2, 2026), making the timing of RTW Investments's position particularly relevant.
Short interest stands at 21.6% of float with 14.2 days to cover, indicating significant bearish positioning against RTW Investments's long thesis.
About Xencor Inc.
Xencor, Inc., a clinical stage biopharmaceutical company, focuses on the discovery and development of engineered monoclonal antibody and cytokine therapeutics to treat patients with cancer and autoimmune diseases. The company provides Sotrovimab that targets the SARS-CoV-2 virus; Ultomiris for the treatment of patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome; and Monjuvi for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma. It develops Plamotamab, a tumor-targeted antibody, which is in Phase I clinical trial to treat non-Hodgkin lymphoma; Vudalimab, a bispecific antibody, which is in Phase II clinical trial to treat metastatic castration-resistant prostate cancer and other solid tumor types; and Tidutamab that is in Phase II clinical trial to treat neuroendocrine tumors. The company is also developing XmAb306, which is in Phase I clinical trial to treat solid tumors; XmAb104 and XmAb841, which are in Phase I clinical trial to treat patients with selected solid tumors; XmAb564 that is in Phase I clinical trial to treat autoimmune diseases; AMG 509, which is in Phase I clinical trial to treat prostate cancer; XmAb819 for patients with renal cell carcinoma; and Novartis XmAb. It develops VIR-3434, which is in Phase II clinical trial for patients with hepatitis B virus infection; VIR-2482 that is in Phase 1/2 clinical trial to trat influenza A; VIR-7832, which is in Phase 1b/2a trial to treat mild-to-moderate COVID-19; and BMS-986414 + BMS-986413 is in Phase 2/3 NIH ACTIV-2 trial in treating COVID-19. The company develops AIMab7195 to reduce blood serum levels of IgE that mediates allergic responses and allergic disease; Obexelimab to treat autoimmune disease; and Xpro1595 to treat patients with Alzheimer's disease, mild cognitive impairment, and depression. It has a license agreement with Caris Life Sciences. Xencor, Inc. was incorporated in 1997 and is headquartered in Monrovia, California.
Full company profile →Short Interest
21.6%
14.2 days to cover
RTW Investments XNCR Position History
Frequently Asked Questions
Does RTW Investments own XNCR?
Yes. As of Q4 2025, RTW Investments holds 6,777,461 shares of Xencor Inc. (XNCR) valued at $103.8M. This data comes from their SEC 13F filing.
How many hedge funds own XNCR?
10 specialist biotech hedge funds currently hold XNCR, including EcoR1 Capital, BVF Partners, Baker Bros. Advisors and 6 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did RTW Investments first buy XNCR?
RTW Investments's position in XNCR was first reported in Q3 2024. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is RTW Investments's XNCR position increasing or decreasing?
RTW Investments increased their XNCR position in the most recent quarter, adding 556,407 shares.
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