EcoR1 Capital ZYME Position
Active6-Fund ConvergenceEcoR1 Capital held their position in Zymeworks Inc. (ZYME) in Q4 2025, holding $604.8M worth of shares across 22,970,388 shares.
The position was first reported in Q1 2023 and has been tracked across 12 quarterly 13F filings.
ZYME is a convergence signal: 6 specialist biotech funds hold this stock, suggesting high institutional conviction.
There is an upcoming Phase 3 readout for Futibatinib in 440 days (Jun 30, 2027), making the timing of EcoR1's position particularly relevant.
About Zymeworks Inc.
Zymeworks Inc., a clinical-stage biopharmaceutical company, discovers, develops, and commercializes biotherapeutics for the treatment of cancer. The company's lead product candidates include zanidatamab, a novel bispecific antibody that is in Phase 1 and Phase 2 clinical trials for the treatment of biliary tract, gastroesophageal adenocarcinomas, breast, and colorectal cancer; and ZW49, a biparatopic anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate that is in Phase 1 clinical trial for the treatment of advanced or metastatic HER2-expressing tumors. The company has strategic partnerships with Merck Sharp & Dohme Research Ltd.; Eli Lilly and Company; Bristol-Myers Squibb company; GlaxoSmithKline Intellectual Property Development Ltd.; Daiichi Sankyo Co., Ltd.; Janssen Biotech, Inc.; BeiGene, Ltd.; and Exelixis, Inc. It also has licensing and research collaboration with LEO Pharma A/S to research, develop, and commercialize bispecific antibodies; and Iconic Therapeutics, Inc. Zymeworks Inc. was incorporated in 2003 and is headquartered in Vancouver, Canada.
Full company profile →Short Interest
8.2%
5.4 days to cover
EcoR1 Capital ZYME Position History
| Quarter | Action | Shares | Change | Value |
|---|---|---|---|---|
| Q4 2025 | Held | 22,970,388 | — | $604.8M |
| Q3 2025 | Held | 22,970,388 | — | $392.3M |
| Q2 2025 | Increased | 22,970,388 | +5,710,840 | $288.3M |
| Q1 2025 | Increased | 17,259,548 | +2,231,469 | $205.6M |
| Q4 2024 | Increased | 15,028,079 | +1,590,606 | $220.0M |
| Q3 2024 | Held | 13,437,473 | — | $168.6M |
| Q2 2024 | Held | 13,437,473 | — | $114.4M |
| Q1 2024 | Held | 13,437,473 | — | $141.4M |
| Q4 2023 | Held | 13,437,473 | — | $139.6M |
| Q3 2023 | Held | 13,437,473 | — | $85.2M |
| Q2 2023 | Increased | 13,437,473 | +3,350,000 | $116.1M |
| Q1 2023 | New | 10,087,473 | +10,087,473 | $91.2M |
Frequently Asked Questions
Does EcoR1 Capital own ZYME?
Yes. As of Q4 2025, EcoR1 Capital holds 22,970,388 shares of Zymeworks Inc. (ZYME) valued at $604.8M. This data comes from their SEC 13F filing.
How many hedge funds own ZYME?
6 specialist biotech hedge funds currently hold ZYME, including BVF Partners, Perceptive Advisors, Redmile Group and 2 more. When 3 or more specialist funds hold the same stock, BiotechEdge flags it as a convergence signal.
When did EcoR1 Capital first buy ZYME?
EcoR1 Capital's position in ZYME was first reported in Q1 2023. 13F filings are reported with a 45-day delay, so the actual purchase may have occurred earlier in the quarter.
Is EcoR1 Capital's ZYME position increasing or decreasing?
EcoR1 Capital held their ZYME position unchanged in the most recent quarter.
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